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Topline Results Are In: Cognition Therapeutics’ Drug To Fight Dementia With Lewy Bodies Shows Encouraging Results In Phase 2 Trial

Benzinga

By Meg Flippin, Benzinga Cognition Therapeutics Inc. (NASDAQ: CGTX), a clinical-stage company developing drugs that treat neurodegenerative disorders including dementia with Lewy bodies (DLB), announced positive topline results of its exploratory phase 2 SHIMMER study for CT1812, its experimental orally delivered small molecule oligomer antagonist to treat this progressive form of dementia. Cognition Therapeutics said the trial demonstrated CT1812 produced strong therapeutic responses across behavioral, functional, cognitive and movement measures in patients with DLB. DLB is a form of dementia in which symptoms come on fast. DLB can quickly lead to a decline in thinking and reasoning as well as independent movements, and can cause uncontrollable changes in alertness, recurring hallucinations, sleep disruptions, tremors and slow movement. It impacts about 1.4 million people in the U.S. and is the costliest form of dementia. As it stands, drugs to cure this debilitating form of dementia are nonexistent, and treatments, which are used off-label focus on managing symptoms. Promise In A Pill “These topline results exceeded our expectations and support the broad potential of CT1812 across neurodegenerative disorders,” Anthony Caggiano, M.D., Ph.D., Cognition’s chief medical officer and head of R&D, said when announcing the results. “Analysis of CT1812’s activity in DLB will continue as additional data become available. We look forward to reporting these findings at future medical meetings and reviewing them with the FDA in an end-of-phase 2 meeting.” The phase 2 SHIMMER study enrolled 130 adults who were randomized to receive either placebo or one of two oral once-daily doses of CT1812 (100 mg or 300 mg) for six months. Participants were assessed throughout the study using the Montreal Cognitive Assessment (MoCA) and Cognitive Drug Research (CDR) Battery, which track cognitive performance; the Clinician Assessment of Fluctuation (CAF) to measure the frequency and duration of cognitive fluctuations; and the MDS-Unified Parkinson’s Disease Rating Scale (MDS-UPDRS) Part III, an objective assessment of parkinsonism. Cognition Therapeutics said the study met its primary endpoint of safety and tolerability, with data showing that DLB patients treated with CT1812 for six months experienced improvement in behavioral, functional, cognitive and movement measures compared to the placebo. Cognition reported an 82% slowing in the total neuropsychiatric inventory (NPI), with a particularly strong reduction in anxiety, hallucinations and delusions in the CT1812 treated arms. In addition, there was a marked reduction in caregiver distress, which suggests a positive impact on the day-to-day lives of those receiving the drug, reports the company. Participants treated with CT1812 experienced a slowing of decline across all three cognitive measures compared to the placebo, including fluctuations in attention which declined by 91%. Cognition plans to present detailed data at the International Lewy Body Dementia Conference (ILBDC) in January 2025. The SHIMMER study is supported by a grant award from the National Institute on Aging of the National Institutes of Health (NIH) totaling approximately $30 million and is being conducted in collaboration with the Comprehensive Center for Brain Health at the University of Miami Miller School of Medicine and the Lewy Body Dementia Association (LBDA). Preceding Trial Had Promising Results Cognition had previously completed a Phase 2 SHINE study to look at CT1812’s effects on treating individuals aged 50 to 85 who have mild-to-moderate Alzheimer’s disease. That study recruited 153 individuals, and the results showed a 95% slowing of cognitive decline in people exhibiting a key Alzheimer’s disease biomarker. “With the SHIMMER and SHINE results, we are confident in CT1812’s clinical activity given that it has demonstrated broad neurologic and neuroprotective activity in DLB and Alzheimer’s disease,” Lisa Ricciardi, Cognition’s president and CEO, said. “People with these diseases, particularly DLB, have few therapeutic options leading to a cascade of symptoms that are painful to the individual and their caregivers. We are eager to continue the development of CT1812 in late-stage clinical trials with the hope of providing a once-daily pill that can treat these devastating neurodegenerative conditions.” To learn more about Cognition Therapeutics and its SHIMMER study, click here. Featured photo by Rad Cyrus on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and is not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

December 20, 2024 08:35 AM Eastern Standard Time

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Quest Diagnostics (NYSE: DGX) And Mainz Biomed (NASDAQ: MYNZ) Team Up To Commercialize ColoAlert Early Cancer Detection Screening In The U.S.

Benzinga

By Meg Flippin, Benzinga Mainz Biomed N.V. (NASDAQ: MYNZ), the molecular genetics diagnostic company specializing in the early detection of cancer, is moving closer to commercializing its early colorectal cancer detection screening ColoAlert® in the U.S. by inking deals with Quest Diagnostics (NYSE: DGX), a leading provider of diagnostic information services. As part of the agreements, Mainz Biomed said Quest Diagnostics will provide clinical trial and laboratory services to support its ReconAAsense Food and Drug Administration pivotal study of ColoAlert. The clinical trial is slated to kick off next year with up to 15,000 patients. If ColoAlert gets the nod from the U.S. FDA, it will be able to target the millions of Americans at risk of colorectal cancer. Mainz has said its commercial strategy is to establish scalable distribution in the U.S. through a collaborative partner program with regional and national laboratory service providers. The recent strategic alliance with Thermo Fisher Scientific (NYSE: TMO), a global leader in life sciences with annual revenue exceeding $40 billion, represents a monumental step forward in transforming cancer prevention in the United States, says Mainz. This partnership harnesses Thermo Fisher's extensive expertise and state-of-the-art infrastructure to drive innovation in healthcare solutions. Adding further depth to this initiative is the collaboration with Quest Diagnostics, a leader in advanced testing and sampling technologies. Quest Diagnostics offers a broad range of services, including routine blood work, genetic and molecular testing and specialized diagnostic services for various diseases, such as cancer, cardiovascular conditions and infectious diseases. Mainz reports that Quest Diagnostics is widely recognized for its national network of laboratories, extensive patient service centers and cutting-edge technology that ensures accurate and timely test results. As a significant player in the healthcare industry, particularly in diagnostic testing and sampling, Quest Diagnostics serves millions of patients and healthcare providers annually, making it a critical component in advancing precision and scalability in early cancer detection and prevention. With $8 million in funding dedicated to expediting FDA approval, this initiative aims to rapidly advance critical milestones, laying the groundwork for massive expansion. Together, Mainz believes these partnerships are poised to catalyze a sweeping transformation in public health outcomes, creating a tidal wave of innovation and economic growth that will ripple across the healthcare landscape. Readying ColoAlert For Potential U.S. Debut In addition to supporting the clinical trial, Mainz said Quest Diagnostics has a semi-exclusive right to market ColoAlert in the U.S. for an eighteen-month period. If exercised, this option will allow Quest Diagnostics the opportunity to offer the product to multiple channels, including physicians, health systems, hospitals, health plans, employers and consumers, reports Mainz Biomed. “We are excited by the opportunity to collaborate with Quest Diagnostics,” commented Guido Baechler, Chief Executive Officer of Mainz Biomed. “Teaming with Quest Diagnostics during our critical FDA Study will be key to our long-term success.” Encouraging Trial Results ColoAlert is an early detection screening that spots bleeding and non-bleeding tumors through tumor DNA analysis. ColoAlert analyzes samples for the four tumor markers associated with cancer: KRAS-mutation, BRAF-mutation, total amount of human DNA and occult blood. By analyzing tumor DNA, Mainz says ColoAlert detects 85% of colorectal cancer cases, often in the very early stages of the disease. Based on recent trials, Mainz Biomed says ColoAlert’s sensitivities exceeded 90% for detecting colorectal cancer and over 80% for advanced adenomas. Detecting advanced adenomas is crucial in preventing colorectal cancer, as identifying patients with these lesions allows for timely intervention through colonoscopy and adenoma removal, thereby averting cancer development, reports Mainz. Big Addressable Market It's a big market for Mainz Biomed to address, given colorectal cancer is the third most common cancer globally, with more than 1.9 million new cases reported in 2020, according to World Cancer Research Fund International. The U.S. Preventive Services Task Force recommends that screening with stool DNA tests be conducted once every three years, starting at age 45. As it stands, 71% of the diagnoses made are in the later stages of the disease. But if it's caught early, the survival rate after five years is 90%. Despite those favorable odds, only about four in ten colorectal cancers are spotted at the early stage. Each year in the U.S., 16.6 million colonoscopies are performed, yet about one-third of US residents aged 50-75 have never been screened for colon cancer. This gap in screening represents a $4 billion total market opportunity in the U.S., according to estimates compiled by Mainz Biomed. ColoAlert, if approved in the U.S., may help rectify that lack of timely screening. After all, Mainz Biomed says its detection system is less invasive than ColoGuard, the leading at-home test in the U.S., because it requires very small samples to test. It’s one of the reasons the company boasts 98% patient satisfaction in Germany. ColoAlert is also easy to use, which should be a big driver of adoption. Within five minutes your sample is collected and packaged and on the way to the lab. Patients receive a kit in the mail that includes instructions, a stool collector and a shipping label to return the kit to their local lab for testing. Patients receive the results in a few days. Mainz Biomed wants to bring its ColoAlert early cancer screening test to the U.S., and it is inking deals and readying clinical trials to achieve that. Its agreements with Quest Diagnostics put it one step closer. Stay tuned in 2025 – there may be lots more to come from Mainz Biomed on its path to commercializing ColoAlert in the U.S. and beyond. Featured photo by National Cancer Institute on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

December 20, 2024 08:30 AM Eastern Standard Time

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Amesite Announces AI-Powered App Winning Enterprise Contracts In Growing Companies With Hundreds Of Franchise Owners – What’s Driving The Momentum?

Benzinga

By Meg Flippin, Benzinga The home healthcare market is in a state of flux. The need for home healthcare workers is soaring as the population in the U.S. ages. In about ten years, 78 million people in the U.S. will be 65 or over. By 2060, The Institute on Aging expects the demographic will increase to 98 million and account for a quarter of the U.S. population. At the same time, the nation is aging, there is a dearth of home healthcare workers, and it looks like it’s only going to get worse. Over the next decade, the institute expects the number of home health aide jobs to grow by 425,000, creating a shortage that will need to be filled. As it stands, about 95% of home and community-based care providers say they face moderate to severe staffing shortages, with 77% turning away new clients because of the lack of workers. What’s more, 72% of providers say staffing shortages make it hard to meet quality standards. If nothing is done, that problem will only get worse. It’s why some home healthcare providers are turning to technology, namely NurseMagic™, for an assist. The brainchild of Amesite (NASDAQ: AMST), NurseMagic is a proprietary AI-powered app designed for nurses and home health care workers. The company reports it has closed on contracts with franchise owners representing nationally recognized brands that operate hundreds of locations across the country – resulting in recurring revenue in a total addressable market it estimates at $330 billion. Streamlining Work, Improving Care The AI-powered app, which Amesite reports has seen explosive growth since its launch this past summer, provides nurses and home healthcare professionals with a handy tool that writes comprehensive documentation instantly, can quickly translate medical terms into easy-to-understand language, create work emails, assist nurses in talking to patients with compassion, coach nurses on taking effective breaks during the day, convert images to text, provide key information about medications and collect instant feedback. Amesite says its AI app integrates seamlessly into the operational frameworks of home care agencies, enhancing workflow efficiency and supporting employee retention by lightening administrative burdens and reducing worker burnout. As a result, AI technology can enable agencies to make the most of existing resources and extend care to more clients who would otherwise be turned away due to staffing constraints, reports Amesite. Take the Senior Helpers franchise in Northern Orange County for one example. Since adopting NurseMagic, owner Steven Nickens said NurseMagic has been empowering his staff to get answers to questions quickly through the app, saving time and ensuring accurate results. “NurseMagic's technology is transforming my organization with its intuitive and easy-to-use platform,” said Nickens. “NurseMagic is both powerful and incredibly easy to use, making it accessible to everyone on my team." Nickens isn’t alone in his assessment. Joshua Porter, owner of the Spokane North BrightStar Care franchise, said he uses NurseMagic to support the company’s rapid growth. "As a new franchise owner with extensive business and engineering experience, I’m thrilled to share how quickly we’re growing. When I discovered NurseMagic, I immediately recognized it as a must-have to stay competitive in today’s market,” said Porter, noting there are no hidden fees or messy contracts when bringing NurseMagic into the fray. Growth Driven By NurseMagic In addition to improving the quality of care for patients, NurseMagic is also aiming to help healthcare franchises grow their businesses. That’s certainly the case at the Fargo Senior Helpers franchise, with owner Tanya Ferber saying the app is enabling her to go after more medically complex clients in the new year. Plus, incorporating NurseMagic into her business attracts more tech-savvy healthcare workers. “It’s a value-added tool for my business and takes our quality to the next level,” says Ferber. It’s not just home healthcare franchises that benefit. Amesite says that by selling NurseMagic to franchise owners from well-known brands in the home health and home care industries, its revenue should grow and cement NurseMagic’s status as a must-have tool. “We made two tactical decisions: first, to build a best-in-class infrastructure that delivers top-tier compliance, security and low operating costs; and second, to price NurseMagic accessibly, at a sustainable margin, focusing on scaling sales rather than maximizing margins with a few customers,” said Dr. Ann Marie Sastry, CEO of Amesite. “These choices position us to meet the strong demand in our industry and drive widespread adoption.” Since launching NurseMagic a mere five months ago, the company says it has met several milestones, including launching a paid individual subscription, meeting HIPAA compliance requirements for paid enterprise customers and generating revenue in the home care market. The U.S. population is getting older at the same time that there is a shortage of nurses and home healthcare workers available to tend to the aging population. Those who are working are stressed and doing more with less. NurseMagic can fill that gap, presenting nurses, home health care workers and franchises with an AI-driven tool to improve the quality of life for workers and the care for patients, the company argues. It's a win-win, which is why Amesite has been hitting so many milestones in 2024, and expects revenue to ramp up in the new year. Featured photo by Dominik Lange on Unsplash. Benzinga is a leading financial media and data provider, known for delivering accurate, timely, and actionable financial information to empower investors and traders. This post contains sponsored content. This content is for informational purposes only and not intended to be investing advice. Contact Details Benzinga +1 877-440-9464 info@benzinga.com Company Website http://www.benzinga.com

December 20, 2024 08:25 AM Eastern Standard Time

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Jaynike Pioneers Digital Transformation with Comprehensive Web Solutions

Rev Up Marketers

As digitalization reshapes global commerce and communication, Jaynike is redefining the standards of web design and digital marketing with its latest suite of enhanced services. Focused on empowering businesses to thrive in the competitive online landscape, Jaynike offers tailored solutions that combine cutting-edge technology with creativity to meet the unique needs of its diverse clientele. Recognizing that every business faces distinct challenges in the digital space, Jaynike offers responsive web design with targeted digital strategies, ensuring seamless user experiences and measurable outcomes. From startups seeking visibility to enterprises aiming to strengthen their digital footprint, Jaynike’s solutions are crafted to enable meaningful engagement with audiences. “At Jaynike, organization believe that a strong digital presence is more than just aesthetics—it’s about creating experiences that resonate and strategies that deliver,” said a spokesperson Named Richard Brown for Jaynike. “Approach is rooted in understanding each client’s vision and transforming it into impactful digital realities.” The enhanced services include state-of-the-art web development, advanced SEO strategies, content marketing, social media management, and precision-targeted advertising campaigns. By blending innovation with personalized attention, Jaynike positions itself as a trusted partner in navigating the complexities of digital transformation. With its customer-first philosophy and a steadfast commitment to excellence, Jaynike.com continues to pioneer advancements in web solutions, empowering businesses to connect, grow, and lead in the digital age. About Jaynike Jaynike is a leading provider of innovative web design and digital marketing solutions, dedicated to helping businesses excel in the digital era. Combining advanced technology with creative strategies, crafting tailored solutions to meet the unique needs. With a focus on measurable results and exceptional user experiences, Jaynike empowers businesses to build impactful online presences and achieve sustainable growth. Contact Details Jaynike Richard Brown support@jaynike.com Company Website https://www.jaynike.com

December 20, 2024 07:49 AM Eastern Standard Time

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Should You Still Buy Dogecoin Over $0.40? Here Are 2 Alternatives Under $1 With More Potential

Cutoshi

At this point, it would be surprising for Dogecoin (DOGE) not to reach $1 and beyond. The meme coin king continues to dominate the space as it cemented itself as a legitimate asset in the broader market. With that being said, there are other altcoins that could surpass Dogecoin in terms of ROI. While Tron (TRX) is an obvious example, a new arrival, Cutoshi (CUTO), could soon take the spotlight. Dogecoin Is Struggling To Breakout After Month-Long Consolidation When Donald Trump won the US presidency in early November, Dogecoin stunned the market with a triple-digit rally that saw its price multiply in the span of a few days. However, shortly after, Dogecoin began stalling as its momentum waned and selling pressure increased. After peaking at $0.47 Dogecoin (DOGE) entered a narrow trading channel with its price fluctuating around the $0.40 mark. On the other hand, whales continue to bolster their Dogecoin position in anticipation of a new rally. Analyst Ali Martinez has shared impressive on-chain numbers on X, highlighting a recent buying spree that saw large wallets spending over $64 million to purchase 160 million DOGE. In regards to Dogecoin’s price action, renowned DOGE bull KrissPax has highlighted a bull flag pattern on the chart. According to Kriss, a breakout above the trendline could propel Dogecoin to $0.69 by the end of the year. If this projection plays out, the prophesied $1 DOGE could become a reality in Q1 2025. Tron Is Retesting Lower Levels After ATH Run Tron (TRX) has been in up-only mode since bottoming out in 2022. In late 2024, Tron entered escape velocity as it tore through major resistance levels with ease and reached a new all-time high for the first time since 2018. However, after tagging the $0.42 peak, Tron’s price started to decline as bears stepped in. At press time, Tron trades at $0.28 following a 6.1% intraday decrease which was accompanied by an 18.8% decline in 24-hour volume, with roughly $1.88 billion worth of TRX traded across exchange platforms. However, analyst Anni Sarahayu points out on X that a Tron is printing a string of higher lows on the 4-hour chart. This teases an incoming breakout which could send Tron soaring to new heights by the end of December. At $24.7 billion, Tron’s market cap is worth less than half of Dogecoin's $60 billion, meaning that investors looking for projects with a proven track record and much greater room for growth could consider adding TRX to their portfolio. However, there could be an even better option. Cutoshi’s Farming Mechanism Is Turning Heads Cutoshi is already making waves with its hybrid framework that merges meme lore with DeFi functionality, creating the first-ever MemeFi ecosystem. The project is centered around CUTO DEX, a cross-chain, fully private, decentralized exchange that could soon give established protocols like Uniswap or Rayidium, a run for their money. Investors will be able to perform lightning-fast transactions on all major blockchains at some of the lowest fees on the market. Japanese Lucky Cats are said to bring prosperity to businesses. Cutoshi brings good fortune to the blockchain. Cutoshi Farming is one of the platform’s most intriguing features. Users will have the opportunity to earn massive prizes while growing their $CUTO portfolio. They will be tasked with completing fun missions aimed at expanding Cutoshi’s online reach. In exchange for their efforts, they will receive CUTO points which can be redeemed for more $CUTO once the token hits the markets. Moreover, a staking option will soon be available as well, allowing holders to put their $CUTO to work and tap into a passive income stream. Stage 4 of the presale is now live and over $1.37 million has been raised so far. $CUTO sells for just $0.031, making this the perfect entry point for early adopters who want to capitalize on this new DeFi-driven meme coin. For more information on the Cutoshi (CUTO) Presale: https://cutoshi.com/ Join and become a community member: https://twitter.com/CutoshiToken https://t.me/cutoshi Welcome to Cutoshi, the revolutionary meme coin, DeFi hub and educational platform inspired by the Lucky Cat and Satoshi Nakamoto’s teachings. Traditionally, people put the Lucky Cat in their homes and businesses to maximize its lucky powers and bring them good fortune and wealth. Now Cutoshi the Lucky Cat is on the blockchain bringing luck, prosperity, and wealth to your digital assets. Cutoshi is creating a path to financial freedom, for those who choose to honor the power of the Lucky Cat. Supporting the principles of freedom, privacy, anonymity, and monetary empowerment for the masses. Cutoshi aims to bring the benefits of blockchain to everyone. The regulatory environment surrounding cryptocurrencies is evolving and varies across jurisdictions. It is your responsibility to ensure compliance with applicable laws and regulations in your country or region before engaging with Custoshi. Contact Details Cutoshi hello@cutoshi.com Company Website https://cutoshi.com/

December 20, 2024 07:45 AM Eastern Standard Time

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Finn and Form Launches Online Stores, Redefining Sensible Luxury with Elegant, Functional, and Affordable Home Decor

Rev Up Marketers

Finn & Form, a pioneering home decor brand that seamlessly blends elegance, functionality, and affordability, is proud to announce the official launch of its online stores in the United States and Canada. This milestone marks the beginning of an exciting chapter for Finn & Form as it introduces its philosophy of “sensible luxury” to discerning customers across North America. What sets Finn & Form apart in the world of home design is the ethos of “sensible luxury.” Finn & Form believes that luxury isn’t about excess—it’s about making thoughtful investments in pieces that elevate everyday living. The brand focuses on high-quality materials, superior craftsmanship, and timeless designs that combine form and function. Finn & Form offers homeowners the chance to indulge in premium experiences without compromising on comfort, practicality, or value. “Sensible Luxury is our brand’s DNA, it is based on the concept of investing smartly and sustainably to enrich your everyday life,” said Linda Lawrence, VP of Corporate Relations of Finn & Form. “Our mission is to craft timeless designs that adapt to the changing needs of contemporary spaces. From modular sectionals that cater to large family rooms to refined dining tables that transform everyday meals into memorable moments, we focus on creating beautiful pieces that are sensible, without the extravagant price tag.” Finn & Form’s designs reflect a perfect blend of sophistication and practicality. Each product incorporates sleek lines, refined textures, and a neutral palette that effortlessly complements modern interiors. The brand prides itself on using eco-conscious, high-quality materials to ensure its pieces are both durable and environmentally sound. Finn & Form invites customers to explore a thoughtfully curated selection of furniture that reflects its commitment to quality and style. Highlights of the core collections include: Living Room Furniture: Luxurious leather recliners, modular sectional sofas, and mid-century modern designs crafted from premium materials such as full-grain leather. Featuring pieces like the Chaumet Leather Reclining Sofa, the Serena Leather Sectional Sofa, the Violet Swivel Chair, each item is designed to balance timeless appeal with modern sensibilities. Dining Solutions: Sophisticated dining tables, including solid wood, walnut, and marble-top designs. Featuring pieces like the Clemente Quartz Dining Table and the Dubois Dining Chair, each design is perfect for elevating every mealtime with a blend of elegance and functionality. Every piece in the online catalog is hand-selected to ensure it meets Finn & Form’s rigorous standards of craftsmanship, style, and versatility. Alongside the launch of its online stores, Finn & Form introduces the F&F Membership Program, a tailored experience that offers unparalleled convenience and value. The Finn & Form online stores have been designed to create an intuitive shopping experience, allowing customers to effortlessly browse a curated selection of leather sofas, chic dining tables, and more. More than a furniture company, Finn & Form is a community of like-minded individuals who share a passion for tasteful living. By offering a seamless blend of style and practicality, the brand continues to build relationships with customers who value craftsmanship and elegance in their home environments. The Finn & Form team invites you to explore their new online collections or learn more about membership benefits, visit F&F Membership Program. About Finn & Form Finn & Form is a luxury home decor brand committed to bringing sensible luxury into contemporary living spaces. With a timeless yet modern design ethos, a focus on high-quality materials, and a dedication to functionality, Finn & Form creates pieces that enrich everyday life. Explore the brand’s curated collections of leather sofas, elegant dining tables, and versatile home accessories at finnandform.com. Contact Details Finn & Form Inc Karin Jones +1 807-809-8244 karin.jones@finnandform.com Company Website https://finnandform.com

December 20, 2024 05:56 AM Eastern Standard Time

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News Release

Exploring the Roles of Random Number Generators at Online Casinos

Acroud Media

Online casinos have revolutionised the gambling world, offering players the thrill of casino games from the comfort of their own homes. But have you ever wondered how these games ensure fairness and unpredictability? The answer lies in the technology called Random Number Generators (RNGs). RNGs are crucial in maintaining trust, fairness, and compliance in online casinos. Our experts delve into the importance, functionality, and impact of RNGs on the gaming experience. What Is a Random Number Generator? A Random Number Generator (RNG) is a sophisticated algorithm or hardware device that generates random numbers, ensuring unpredictable and free-from-manipulation outcomes in games. RNGs form the backbone of many online casino games, including slots, roulette, blackjack, and poker, where randomness is essential to simulating the unpredictability of real-world gambling. Variations of RNGs in Online Casinos There are two main types of RNGs used in online casinos: Pseudo-Random Number Generators (PRNGs) - PRNGs use a mathematical formula or algorithm to produce a sequence of numbers that appear random. While they are not genuinely random because they rely on an initial seed value, their complexity ensures that predicting the sequence is practically impossible. True Random Number Generators (TRNGs) - TRNGs, on the other hand, generate randomness by capturing unpredictable physical phenomena, such as electrical noise or atmospheric conditions. These are less common in online casinos due to higher costs and complexity but are considered genuinely random. How RNGs Work in Online Casino Games RNGs operate by continuously generating sequences of random numbers, even when no games are being played. When a player initiates an action, like spinning the reels on a slot or drawing a card in blackjack, the RNG selects a random number from its sequence. We have explained how RNGs work in the following casino games: Online Slots: RNGs determine the symbols that appear on the reels after a spin. Each spin is independent of the last, ensuring fair play. Roulette: RNGs are used to generate the random number corresponding to the winning pocket. Card Games: RNGs shuffle and deal cards virtually, mimicking the unpredictability of a live dealer. Why RNGs Are Crucial for Online Casinos RNGs are integral to the functioning of online casinos for several reasons: Fairness - RNGs ensure every outcome is random and independent, preventing bias or manipulation by the casino or players. Compliance with Regulations - Reputable online casinos operate under strict licences that require the use of certified RNGs. These licences are issued by regulatory bodies such as the UK Gambling Commission or the Malta Gaming Authority. Building Player Trust - Players need to feel confident that the games they play are fair. RNG certification from third-party auditors like eCOGRA or GLI reassures players about the integrity of the casino. Preventing Patterns - In the absence of RNGs, patterns could emerge, leading to predictability. RNGs eliminate this risk, keeping games exciting and uncertain. How RNGs Are Tested and Certified To maintain fairness, RNGs undergo rigorous testing and certification by independent auditing bodies. These organisations assess several factors, including: Randomness: Ensuring no discernible patterns in the outcomes. Consistency: Confirming the RNG produces random results under all conditions. Security: Evaluating whether the RNG is immune to tampering or hacking. Some prominent testing organisations include: eCOGRA: An internationally recognised testing agency that certifies RNGs for fair play. GLI (Gaming Laboratories International): A leading independent certification body for RNG testing. iTech Labs: Known for its detailed RNG evaluations. RNG Myths and Misconceptions Despite their importance, RNGs are often surrounded by myths and misconceptions, with the first being that “RNGs Can Be Manipulated by the Casino”. Licensed online casinos cannot tamper with RNGs, as third-party agencies regularly audit them. Any manipulation would risk the casino losing its licence and damaging its reputation. The next RNG misconception we are here to debunk is that “Games Have Hot or Cold Streaks”. RNGs ensure each spin or game is independent. The concept of hot or cold streaks is purely psychological and has no basis in the mechanics of RNGs. The final RNG myth is that “RNGs Favour the House”. While online casino games are designed with a house edge, this is separate from the RNG. The RNG ensures fairness, while the house edge is built into the game rules. Benefits of RNGs for Players RNGs offer numerous advantages to players: Fair Play: Ensures every player has an equal chance of winning. Consistency: Outcomes remain fair regardless of the time of day or number of players. Convenience: Players can enjoy a realistic gaming experience without needing a physical casino. Variety: Enables the development of unique game mechanics and themes. How to Verify RNG Fairness When Choosing an Online Casino To ensure a safe and fair gaming experience, follow these steps when selecting an online casino: Check for Licensing - Look for casinos licensed by reputable authorities like the UK Gambling Commission. Look for Certifications - Ensure the casino’s RNG is certified by independent auditors like eCOGRA. Read Reviews - Browse player reviews and expert recommendations to assess the casino’s trustworthiness. Test the Games - Play demo versions to observe the randomness and gameplay mechanics before wagering real money. Conclusion Random Number Generators are the unsung heroes of online casinos, ensuring that every spin, shuffle, or roll of the dice is fair and unbiased. By combining advanced technology with rigorous testing, RNGs create a secure and thrilling gaming experience for players worldwide. Whether spinning the reels at a leading online casino like Sky Vegas or strategising in a virtual card game, you can thank RNGs for keeping the excitement alive. When choosing an online casino, always look for proper licensing and RNG certifications to ensure a fair gaming experience. With advancements like blockchain and AI on the horizon, RNGs are set to play an even more vital role in shaping the future of online casinos. So, next time you log in to play, you’ll know precisely how these intricate systems work to make your gaming experience fair and fun. Contact Details Acroud Media info-media@acroudmedia.com

December 20, 2024 05:12 AM Eastern Standard Time

Action 24/7 Sportsbook Partners with WagerWire for Betting Marketplace and Media Services

WagerWire

Action 24/7, a major Tennessee sportsbook, today announced it is partnering with California-based sports betting technology and media provider WagerWire to launch ActionWire™, a marketplace for active sports bets on the Action 24/7 sportsbook. This first-of-its-kind partnership will give Tennessee sports bettors unprecedented value and optionality, enabling them to buy and sell previously placed wagers on an open secondary market. The partnership kicks off with a marketing and media collaboration as the two companies work towards integrating the marketplace into the Action 24/7 app. This marks the latest online sportsbook in the United States to implement WagerWire’s revolutionary secondary market feature, which has also proven to be very successful in daily fantasy and social casino settings. “We’re proud to bring innovation directly to our Tennessee community,” said Andrew Jacks, GM, of Operations at Action 24/7. “ActionWire is more than just a feature; it’s a game-changer for how our players connect with and control their bets. Offering such a differentiating feature will continue to make us an attractive option for bettors looking for a sportsbook that focuses on player empowerment.” The marketplace allows bettors to treat their wagers as liquid assets that can be bought and sold, in whole or in part, at any time until the buzzer, creating a new standard for innovation and player engagement in the online sports betting industry. “Our mission is to empower bettors and unlock value for operators, so we are thrilled to be working with the team at Action 24/7 that also live by these principles and go above and beyond to cater to their passionate local fanbase in the Tennessee market.” said Zach Doctor, WagerWire CEO. “This marks another important milestone for our company as we bring our solution to the licensed OSB market following the great results we’ve seen so far in other forms of real money gaming.” As part of the partnership with Action 24/7, Tennessee’s only locally-owned sportsbook, WagerWire will amplify big ticket stories to generate brand awareness for the sportsbook as well as secure potential buyers. One such example unfolding in real time is with a Tennessee bettor named Calvin who holds a parlay with the final leg hinging on Ohio State winning the 2025 College Football National Championship. “I stand to win $437,000 if Ohio State wins the championship, but between a tough path and a wide-open field, the Buckeyes still have their work cut out for them,” Calvin said. “If this was an Action 24/7 ticket I could post it on ActionWire and engage offers for all or part of it, as opposed to just sitting back and hoping Ohio State can win four consecutive tough games. I imagine any bettors in a similar position would love to have the ability to sell at least part of a bet like this.” WagerWire and Action 24/7 will also combine to participate in social media engagement across TikTok, Instagram, YouTube, and X, with a focus on community-driven storytelling as well as contests, giveaways, branded ad wrappers on video content, and hyper-targeted campaigns for Tennessee bettors. Wire Media, WagerWire’s media arm, has seen rapid growth since its launch in early 2024, signaling a strong foundation for driving the partnership's marketing and engagement strategies. About Wire Industries Wire Industries Inc was founded with the mission to bring a more efficient, open, and entertaining market to real money gaming of all types, unlocking value for the entire ecosystem. The company was established in 2021 with its flagship brand WagerWire and now owns and operates Wire Technologies and Wire Media Group. Wire Technologies includes the company’s in-house data science team and core marketplace platform that powers WagerWire, FantasyWire, PonyWire and ContestWire, while Wire Media Group operates their media network and affiliate marketing division. You can download the WagerWire app in the Apple App Store and Google Play, and find them @WagerWire on Twitter/X, TikTok, and LinkedIn, and @WagerWireLive on Instagram. Wire Industries is dedicated to providing a responsible gaming environment. If you think you or someone you know may have a gambling problem, resources are available. Call 1-800-GAMBLER or reach out to their Chief Responsibility Officer Carolina Young directly at live@wagerwire.com. About Action 24/7 Founded in 2020, Action 24/7 is a by Tennesseans for Tennesseans sportsbook based out of Nashville, TN. Action 24/7 is the only locally owned and operated Tennessee sportsbook offering high market limits. Action 24/7 never limits players, offers instant withdrawals, and offers a world-class customer experience. Winners are always Welcome. www.action247.com. Contact Details Bailey Irelan birelan@hotpaperlantern.com Company Website https://www.wagerwire.com/

December 19, 2024 02:51 PM Eastern Standard Time

A Bullish XRP Flag Emerges As Speculation Heats Up For $5, Floki And Cutoshi Set For Better ROI

Cutoshi

Ripple (XRP) is currently in consolidation mode after a memorable triple-digit rally that saw it scale the crypto ranks with ease. However, it seems that the rally is far from over, as bullish signals have started flashing again on the chart, teasing the next leg up. Meanwhile, amid the meme coin craze, investors have started shifting their attention toward utility-focused memes such as Floki (FLOKI) and Cutoshi (CUTO). Is Ripple Ready To Fly Again? Here’s What Analysts Say Between November and early December, Ripple (XRP) stunned the crypto space with a 400% surge that saw it peak at $2.83, a level unseen since 2018. Predictably, a pullback followed once holders began taking profit, forcing a retest of the $2 floor. At the time of writing, Ripple trades at $2.45 with 1.8% in daily gains and a 16.5% decline in 24-hour volume, with roughly $9.8 billion worth of XRP changing hands on trading platforms. Experts agree that Ripple could be on the verge of a massive breakout. Analyst AllInCrypto confirms this thesis as he draws attention to a bull flag formation on the 4-hour chart. Once Ripple flips the descending trendline, it could enter escape velocity, possibly surpassing $5 by the end of the year. This potential is also reflected by the series of catalysts lining up for Ripple. For starters, regulators have greenlighted the release of the highly anticipated Ripple stablecoin RLUSD. Moreover, financial giants and fund managers, including Greyscale and Wisdomtree, have already submitted their applications for a Spot XRP ETF, which will entice institutional clients to start investing in Ripple at scale. Floki Is Building A Foundation For The Next Moonshot. Right now, Floki (FLOKI) sells for $0.00024 with a 5.5% weekly increase and it has been moving in a narrow channel around this mark for the past month. Floki has yet to attempt a reclaim of the $0.00034 all-time high that was tagged in June, but this could happen at any time, as volume has been on the rise and interest is growing steadily. Analyst CryptoBull has drawn an interesting parallel between Floki’s current price action and the performance of Cardano in 2021. He points out that Floki is closely following Cardano’s previous movements and that its current range could serve as a springboard that could propel Floki to new heights. Moreover, Floki’s long-awaited metaverse game Valhalla is set to launch in early 2025. This coincides with the expected resurgence of the crypto game, which is a narrative that has been missing from the landscape. Cutoshi Is Spearheading The MemeFi Revolution. Cutoshi merges meme vibes and DeFi functionality in a single, innovative platform. With this unique blend, the project wants to redefine meme coins as something more than purely speculative assets. Japanese Lucky Cats are said to bring good luck to businesses, while Cutoshi brings good luck to the blockchain, embodying the values of privacy and decentralization. The cornerstone ideals that drove Satoshi Nakamoto to create Bitcoin. At the center of Cutoshi’s ecosystem is CUTO DEX, a decentralized exchange that will allow for near-instantaneous transactions across multiple blockchains for just 0.25% in fees. Users can also participate in the Cuto Farming initiative and complete various missions and tasks aimed at boosting Cutoshi’s presence on social media. For their loyalty, they will receive CUTO points that can be redeemed for $CUTO tokens once the presale wraps up. Stage 4 of the presale is now underway and so far, over $1.37 million has been raised. Tokens are on sale for just $0.031, a perfect entry point for early adopters, as the price is expected to soar much higher in the upcoming months. For more information on the Cutoshi (CUTO) Presale: https://cutoshi.com/ Join and become a community member: https://twitter.com/CutoshiToken https://t.me/cutoshi Welcome to Cutoshi, the revolutionary meme coin, DeFi hub and educational platform inspired by the Lucky Cat and Satoshi Nakamoto’s teachings. Traditionally, people put the Lucky Cat in their homes and businesses to maximize its lucky powers and bring them good fortune and wealth. Now Cutoshi the Lucky Cat is on the blockchain bringing luck, prosperity, and wealth to your digital assets. Cutoshi is creating a path to financial freedom, for those who choose to honor the power of the Lucky Cat. Supporting the principles of freedom, privacy, anonymity, and monetary empowerment for the masses. Cutoshi aims to bring the benefits of blockchain to everyone. The regulatory environment surrounding cryptocurrencies is evolving and varies across jurisdictions. It is your responsibility to ensure compliance with applicable laws and regulations in your country or region before engaging with Custoshi. Contact Details Cutoshi hello@cutoshi.com Company Website https://cutoshi.com/

December 19, 2024 02:28 PM Eastern Standard Time

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