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New Drugs And Therapies Are Giving MS And ALS Sufferers New Hope

Pasithea Therapeutics Corp.

People suffering from incurable neurological diseases such as multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS) hope new therapies and drugs will arrive sooner than later. A chronic and inflammatory neurodegenerative disease, MS affects 400,000 people in the United States and 2.1 million people worldwide, according to the latest data from the National Institutes of Health (NIH). Affecting quality of life, employment, social relationships, and productivity, MS costs the U.S. healthcare system anywhere from $8,528 to $52,244 per patient per year. MS is a potentially disabling disease affecting the brain and spinal cord — the body’s central nervous system. The immune system of those with MS attacks the myelin, the protective sheath covering a person’s nerve fibers. It interrupts communication between the brain and the functions of the body. The end result for many people is permanent damage or deterioration of the nerves. Signs and symptoms of MS vary widely and depend on the amount of nerve damage and which nerves are affected. Some people with severe MS may lose the ability to walk independently, while others may experience long periods of remission without new symptoms. Recent ALS Research Spurs Optimism Although there is no recent data revealing the number of people in the U.S. affected by ALS, an estimated 31,000 people have the condition and an average of 5,000 new patients are diagnosed each year, according to 2017 statistics from the Centers for Disease Control and Prevention. Age-related ALS mainly strikes people between 55 and 75 who live only two to five years after symptoms develop. Also called Lou Gehrig’s disease for the New York Yankee great who died of ALS in 1941, the disease belongs to a broader group of disorders known as motor neuron diseases which cause the gradual deterioration and death of motor neurons. Motor neurons are nerve cells extending from the brain to the spinal cord and muscles throughout the body. As motor neurons degenerate, they stop sending messages to the muscles, which gradually grow weaker, twitch and suffer from atrophy. Eventually, the brain loses its ability to initiate and control most voluntary movements such as walking, chewing, and talking. Merck & Co. Inc. (NYSE: MRK) recently announced it’s paying $25 million to kick off a research partnership with biotech startup Cerevance, which analyzes donor brain tissue to find novel targets for new drugs for neurological disorders. Cerevance’s best-known program is geared toward another incurable neurological disease — Parkinson’s — but Merck will determine whether the technology can help it discover and develop new drugs to treat Alzheimer’s disease. Recent news in the MS research space touted Clene Inc. ’s (NASDAQ: CLNN) results from its Phase 2 VISIONARY-MS trial of CNM-Au8, an investigational gold nanocrystal suspension. The trial began before COVID-19 and ended prematurely, limiting enrollment to 73 of the 150 planned participants. Pasithea Advances Trials For MS And ALS Pasithea Therapeutics Corp. (NASDAQ: KTTA), a biotechnology company focused on researching and discovering new and effective treatments for psychiatric and neurological disorders, announced its investigational MS vaccine PAS002. Trials of the vaccine have effectively delayed disease onset and reduced disease severity in a mouse model of the neurodegenerative condition, according to its preclinical study data. The vaccine, designed to promote immune tolerance to a specific myelin protein, also reduced the severity of relapses and helped the animals gain weight, indicating a better overall health status. “Although early-stage data, we’re thrilled with the results of this study and the strong preclinical efficacy data of our tolerizing approach,” Pasithea CEO Dr. Tiago Reis said. Pasithea Therapeutics has also recently received a $700,000 grant to further its research into anti-integrin antibodies as potential treatments for ALS. The company is developing a monoclonal antibody (mAbs) for treating ALS and other neuroinflammatory disorders. A particular integrin, called alpha-5/beta-1 or fibronectin receptor, has been found at high levels in certain immune cells in an animal model of ALS carrying mutations in the SOD1 gene. Mutations in this gene are estimated to account for up to 20% of familial ALS cases and up to 3% of sporadic ALS cases. The Alpha-5/beta 1 study found that integrin expression is significantly increased in ALS animal models and post-mortem human ALS and significantly upregulated with disease progression. Pasithea has multiple monoclonal antibody candidates against the alpha-5/beta-1 integrin. Treatment with these antibodies has extended survival and improved motor function in the SOD1 mice model of ALS, suggesting a novel mechanism to treat patients with ALS. For more information on Pasithea Therapeutics, visit www.pasithea.com. Pasithea Therapeutics Corporation is a biotechnology company focused on the discovery, research and development of new and effective treatments for central nervous system (CNS) disorders. With an experienced team of experts in the fields of neuroscience and psychopharmacology, Pasithea is developing new molecular entities for the treatment of psychiatric and neurological disorders, including Amyotrophic Lateral Sclerosis (ALS) and Multiple Sclerosis (MS). Pasithea addresses the needs of patients currently suffering with mental illness by providing access to IV ketamine infusions both in clinics and in-home settings. This post contains sponsored advertising content. This content is for informational purposes only and is not intended to be investing advice. Contact Details TraDigital IR- Camille Baptiste camille@tradigitalir.com Company Website https://www.pasithea.com/

October 10, 2022 09:39 AM Eastern Daylight Time

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Hong Kong Baptist University research unveils association between plasma metabolites and COVID-19 antibody levels in recovered patients

Hong Kong Baptist University

HONG KONG SAR - Media OutReach - 10 October 2022 - A study led by Hong Kong Baptist University (HKBU) has revealed the association between rapidly fading antibody levels in some recovered COVID-19 patients and a high plasma concentration of a metabolite called glycylproline (gly-pro) and its producing enzyme. A research team led by Professor Cai Zongwei (left) and Dr Yang Zhu (right) has revealed the association between rapidly fading antibody levels in some recovered COVID-19 patients and a high plasma concentration of a metabolite called gly-pro and its producing enzyme. The researchers also found that the application of an inhibiting agent can counteract the activities of gly-pro and its producing enzyme, and this helped to maintain COVID-19 antibody levels in a mouse model. The findings offer important insights that could aid the development of novel therapeutic and vaccination strategies against the virus. The research results have been published in the Proceedings of the National Academy of Sciences (PNAS), a renowned international scientific journal. Antibody levels drop in some recovered COVID-19 patients The levels of COVID-19 antibodies among individuals in a community are crucial for herd immunity against the virus. In general, recovered COVID-19 patients have high antibody levels as a result of their natural immune reactions. However, antibody levels in some recovered COVID-19 patients have been seen to drop rapidly over the course of a few weeks, and the underlying mechanism of this phenomenon remains poorly understood. Since the beginning of the pandemic, research studies have revealed changes in plasma cytokine and metabolite levels in COVID-19 patients. Based on these observations, a research team led by Professor Cai Zongwei, Chair Professor of the Department of Chemistry and Director of the State Key Laboratory of Environmental and Biological Analysis, and Dr Yang Zhu, the first author of this paper and a Research Assistant Professor of the Department of Chemistry at HKBU, investigated how plasma cytokines and metabolites are associated with antibody levels in recovered COVID-19 patients. Metabolite gly-pro associated with antibody levels The research team analysed the cytokine and metabolite profiles in the plasma samples of three subject groups. The first group included 17 recovered COVID-19 patients with steady COVID-19 antibody levels; the second group included 30 recovered COVID-19 patients with rapidly fading COVID-19 antibody levels; the third one was a control group comprising 35 individuals who had not been infected with COVID-19. A series of quantitative computational analyses that involved the use of machine learning techniques were used to compare the levels of different plasma cytokines and metabolites in the three subject groups in relation to their COVID-19 antibody levels. The researchers then compared the two recovered patient groups with the control group, and any cytokines and metabolites with significantly different levels between the two groups and the control group were shortlisted. Among the shortlisted targets, the levels of seven cytokines and 20 metabolites were seen to differ significantly between the two groups of recovered COVID-19 patients. The researchers then analysed the association between the selected cytokines and metabolites and COVID-19 antibody levels in recovered patients. From the collected data, they concluded that the plasma concentration of the metabolite gly-pro had increased the most in the two recovered patient groups compared with the control group. Overall, the levels of gly-pro in the recovered patient group with rapidly fading antibody levels were four times higher than the control group, while the levels of gly-pro in the recovered patient group with steady COVID-19 antibody levels were two-and-a-half times higher than the control group. Based on these results, the researchers investigated the relationship between COVID-19 antibody levels in recovered patients and gly-pro, as well as the producing enzyme of gly-pro which is named dipeptidyl peptidase-4 (DPP4). Inhibiting gly-pro maintains steady antibody levels The research team set up a four-week mouse model experiment to test the hypothesis that high gly-pro levels are associated with a rapid drop in COVID-19 antibody levels in recovered COVID-19 patients. Four groups of 12 mice were injected with the spike protein of the COVID-19 virus. The groups were then respectively treated with: (1) exogenous gly-pro; (2) an inhibitor that blocks the degradation of endogenous gly-pro; (3) exogenous gly-pro and a DPP4 inhibitor (Sitagliptin, which is also an anti-diabetic drug); and (4) saline. The serum COVID-19 antibody levels in all groups were similar in the first week of the experiment. The antibody levels of the mice in the first group declined after the second week, suggesting that increased gly-pro levels are associated with a decline in COVID-19 antibody levels. The antibody levels of the mice in the second group, who had relatively steady gly-pro levels, also began to decline in the third week. The slower decline in antibody levels in the second group of mice compared to the first group shows that varying amounts of gly-pro are associated with the amount of time a steady antibody level can be maintained. Meanwhile, the antibody levels of the mice in the third group remained stable throughout the experiment. This shows that when the activities of DPP4 are inhibited, the negative effects of gly-pro can be neutralised, and a steady level of COVID-19 antibodies can be maintained. New insights for therapeutic and disease control strategies Professor Cai said: “Effective shield immunity for a community against the spread of COVID-19 is highly dependent on the maintenance of steady antibody levels in individuals. Our experimental results suggest that DPP4 inhibitors can effectively maintain steady antibody levels in COVID-19-infected mice. As a result, our study offers important insights into how we can develop a similar medical approach to maintain COVID-19 antibody levels in humans, which will contribute to the global fight against the pandemic.” Dr Yang said: “Further studies based on our research findings are warranted to explore the potential in other areas of therapeutic and disease control, especially in terms of other applications. For example, novel strategies may be developed to enhance the efficiency of vaccination in boosting antibody levels in humans, particularly in diabetic patients, a well-known high-risk population for COVID-19.” Contact Details Communication and Public Relations Office, HKBU Winnie Shum +852 3411 5262 hkbunews@hkbu.edu.hk

October 10, 2022 09:00 AM Eastern Daylight Time

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Elsevier and the Society of Hospital Medicine Announce Joint Initiative Aimed at Helping Patients With Underlying Substance Use Disorders (SUD)

Elsevier

Elsevier, a global leader in evidence-based clinical practice content, research publishing and information analytics, today announced that it will partner with the Society of Hospital Medicine (SHM) in the development of materials to help hospitalists at the point-of-care with the identification, inpatient management, and discharge planning of patients with underlying substance use disorders (SUD). More than 17 million U.S. adults are affected by SUD and its underlying health conditions. As part of this initiative, Elsevier has provided grant support to enable the Society of Hospital Medicine to develop a suite of tools and resources for hospitalists that will help them in identifying patients with SUD, initiating medications for opioid use disorder (MOUD) in the hospital setting, and supporting patient discharge to the home or community. Faculty working on the project have access to evidence-based information through Elsevier’s ClinicalKey® to inform their research. At project completion, SHM will contribute to the creation of point-of-care recommendations on the topic within ClinicalKey, allowing ClinicalKey users to quickly access the information, while reinforcing best practices recommended by SHM. “Hospitalization represents an important step in identifying and treating patients with SUD,” said Josh Schoeller, President, Clinical Solutions, Elsevier. “It’s imperative to support hospitalists in acquiring the knowledge, evidence-based strategies and tools to effectively manage this patient population and address the growing health crisis in our country.” The first output of this project, due to release this year, will be a discussion guide to support hospitalists in conducting patient-centered discussions with individuals who have a diagnosis of SUD with a focus on Opioid Use Disorder (OUD) including best practices and clinical scenarios in a case study format which review how to identify patients with OUD, initiate treatment and facilitate effective transitions of care strategies. “We’re pleased to collaborate with Elsevier on this important initiative that we believe will have an impact in the health and wellbeing of many Americans suffering from substance use disorders,” said Jenna Goldstein, Director of SHM’s Center for Quality Improvement. # # # About the Society of Hospital Medicine Representing the fastest growing specialty in modern healthcare, the Society of Hospital Medicine (SHM) is celebrating 25 years as the leading medical society for hospitalists and their patients. SHM is dedicated to promoting the highest quality care for all hospitalized patients and overall excellence in the practice of hospital medicine through quality improvement, education, advocacy, and research. Over the past decade, studies have shown that hospitalists can contribute to decreased patient lengths of stay, reductions in hospital costs and readmission rates, and increased patient satisfaction. For more information about SHM and hospital medicine, visit hospitalmedicine.org. About Elsevier As a global leader in information and analytics, Elsevier helps researchers and healthcare professionals advance science and improve health outcomes for the benefit of society. We do this by facilitating insights and critical decision-making for customers across the global research and health ecosystems. In everything we publish, we uphold the highest standards of quality and integrity. We bring that same rigor to our information analytics solutions for researchers, health professionals, institutions and funders. Elsevier employs 8,700 people worldwide. We have supported the work of our research and health partners for more than 140 years. Growing from our roots in publishing, we offer knowledge and valuable analytics that help our users make breakthroughs and drive societal progress. Digital solutions such as ScienceDirect, Scopus, SciVal, ClinicalKey and Sherpath support strategic research management, R&D performance, clinical decision support, and health education. Researchers and healthcare professionals rely on over 2,700 digitized journals, including The Lancet and Cell; our 43,000 eBook titles; and our iconic reference works, such as Gray's Anatomy. With the Elsevier Foundation and our external Inclusion & Diversity Advisory Board, we work in partnership with diverse stakeholders to advance inclusion and diversity in science, research and healthcare in developing countries and around the world. Elsevier is part of RELX, a global provider of information-based analytics and decision tools for professional and business customers. Contact Details Dan DiPietro-James, Global Director, Media Relations dan.james@elsevier.com Company Website https://www.elsevier.com/en-xs

October 10, 2022 09:00 AM Eastern Daylight Time

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5 Best Resume Writing Services: Reviews of the Professional Companies Near You

Resume Builders

Getting started on a job does not come automatically. It begins with an application process for the same role. And a major part of this procedure is submitting a well-written resume. Otherwise called a CV, your resume is one of the essential documents you present in a job search or application for opportunities. As a matter of fact, it is the most important document in the entire procedure. It can make or mar your application process for that fellowship, postgraduate studies, internship, or other work-related bids. Thus, you need your resume to be in top form consistently. But here's the twist, not everyone knows how to write a resume. It is a technical document. Thus, you might find it challenging to write. In fact, if you do, sometimes you have a greater chance of shortchanging yourself. Why? Because it might not pass the ATS. That is the Application Tracking System. And guess what? Most companies now use this tech mechanism to weed through irrelevant and not-well-written resumes submitted through their application portals. Do you want to be a part of these unscreened resumes? I bet not. This is why you need to get an expert to work on your resume, don't you think? Speaking of resume-writing experts, this is what this article centers around. Oh, you will love this! We have carefully worked on a list of the best resume-writing services you could ever have. They were not chosen via random picks. No. They were chosen through a thorough process of fishing out the quality from the substandard in the market. Interestingly, many of these services are attested by the numerous positive comments and feedback on their works across many reliable review sites, such as Site Jabber and Trust Pilot. Without further ado, here is the list of the 5 best resume writing services: PaperHelp - Best resume writing service overall 101Resumes - Professional resume writers from the USA Studdit - Affordable resume writing company 99Papers - High-quality resumes for an executives Ivory Research - CV resume writing service from the UK So, you have nothing to fear. We have carefully curated this list of professional resume writing services based on the excellence of their writing, their originality, how their pricing is set, their customer service, and of course, prompt delivery of written resumes. TOP 5 Professional Resume Writing Services #1. PAPERHELP PaperHelp is a writing service that stands true to its name. They help people all around the world to craft excellently written papers to position them as top-notch candidates in their academic pursuits. For their resume works, though, their works span beyond the student environment. Having been in the market for over a decade, they are one of the most reliable platforms to meet your resume writing needs. No types of resumes are out of their reach. They can get it done for you at lightning speed. Thus, a major part of their selling point is prompt delivery. Little wonder they are referred to as the best professional resume writing service in the United States, and by extension, all regions of the world where students need resumes. Interestingly, it's not only students who need resumes. Thus, anyone is welcome to their service any day, all day. It is noteworthy that PaperHelp is an online custom writing service that offers a wide range of writing services. However, resume writing is one of their flagship services. And they have proven themselves to be an excellent place to turn to when needing a top-notch resume for your application. Their excellence in the market is directly linked to the premium quality of their resumes and CVs. Their work is distinct as they have done several times for people who patronize them. Their website is littered with well-curated positive reviews from clients in the past and present who have had their resumes written with them. You could hardly blame the clients who are enthusiastic to drop great reviews. The PaperHelp army of writers is one of the best in the market. They are professional, qualified, detailed, and hands-on. When you get to the service website to order a resume, there is always a writer ready to attend to you with the best service possible. Because these writers are Ph.D. and Masters degree holders, they are simply stellar hands on deck, ready to provide you with premium resume writing that best reflects any type of application you are looking to pursue. This team of experts efficiently works on your skills, experience, background, competencies, and accomplishments. And they present them in such an irresistible way that many recruiters have made PaperHelp clients their preferred candidates. Another interesting fact that stands PaperHelp out of the crowd is its customer service. Oh, it is remarkable. Many customers keep going back to them for their writing needs because of this reason. The high-quality nature of their client service is based on a sterling level of communication. PaperHelp customer support is available 24/7. And they make ordering for them interactive enough that you can track your order via live chat. You can also manage your order through email, SMS, the PaperHelp app, and Facebook Messenger. It gets all the more interesting to know that PaperHelp has a lot of discounts and freebies for their customers. You can get an excellent resume starting from $45. Yet, as a client, you can still get up to a 15% discount, especially if you are a first-time customer. This is apart from other referral and loyalty programs. For their referral program, it gives you up to $250 for people who use your link to place an order. This platform is also known for the free revisions that its client gets. The stunning refund policy is also not out of the equation. If you are looking to make some corrections to your resume or it so happens that you are not satisfied with their work, you can request a revision or refund. #2. 101RESUMES 101Resumes ranks high among the best resume writing services in the Unites States today. And the reason for this is simple - company based in Chicago. They have positioned themselves in the market through their quality work. So, if you are looking to get that job of your dreams and you need a reliable CV to give you leverage, you should consider reaching out to them. Ordering from them means that you would be buying from a platform that has a lot of great reviews from clients in the past and present. These feedbacks are not only from resume writing. They are also gotten via remarkable delivery on cover letters, CVs, personal statements, statements of purpose, etc. If you want to know one of the most impressive things about this 101Resumes, then the seamless ordering process will stand out. The interface is easy to navigate. It allows you to move freely and make fewer mistakes while ordering from them. By simply selecting your career level, your package, the type of job, and the appointed deadline, you are good to go. Other information in this process would include uploading your details and requirements. And with all that, you are set to order from their website. Definitely, creating an account would be needed. However, the registration and information-gathering process should take an average of 4 minutes. So, with a uniquely simple interface and stress-free ordering process, you are ready to go! Furthermore, 101Resumes has one of the market's considerably fair resume writing prices. With just $99, you can get one of the best resumes in the market written for you. And the prices, as with other online writing services, vary depending on your grade. That, the career level for which you are writing the resume would largely determine the price range with which your work would be written. But not only that, other factors could affect the price of your work. One is if the deadline for which you need the resume is shorter than the usual time that the platform stipulates that the work would be ready. Thus, you might have to pay an extra fee to fast-track the writing. Hence, the price is jerked up. Also, 101Resumes stands as a specialized company. They maintain writing solely career-related technical documents. That is, resumes, cover letters, and CVs. Thus, seeing that their expert writers are targeted in that direction, they churn out more quality works based on this expertise than other services that render additional services. So, you can be sure that more attention is paid to details. And by the way, it takes an average of 4 days for the CV to be delivered. And with this level of speed, the quality is not compromised. It sure would make you look good before any prospective employer looks through the resume. #3. STUDDIT Studdit is that one-stop shop that caters to all your writing needs and particularly provides you with excellent technical and federal resume writing services. With hundreds of reviews lauding their praise in the market, they would get your CV written from scratch or take it from where it is to where you need it to be. Their presence in the market speaks of possibilities. They have shown many new online writing services that a platform can have students and job applicants flock to their websites to get their resume writing done. And guess what? They always deliver excellently. This resume writing platform is available to take all writing services because of its team of professional freelance writers. They are simply good at what they do. Thus, it makes it easier to get high-quality work from them every time they write. A good thing here is that Studdit has a great in-house culture of treating their writers well. Thus, they are more than enthusiastic about delivering promptly as they are given tasks. Sources note that you will never be given a new order to work on as a writer unless you finish a previous one on your hands. Writers are rewarded when they bring clients to the platform. So, as a person ordering, you can rest assured that your work is being handled by people keen to do their work. Hence, you can be sure of a great writing outcome. Furthermore, if you are looking to explore a stressless option for ordering your resume online, Studdit is that place. How so? Their website makes it super-easy to get your orders across. You do not have to sweat due to complications and complexities during the ordering process. Everything is straightforward. The steps to order usually include picking the type of essay (in this case, it would be a resume), specifying the details of the resume, choosing the deadline, selecting the writer you'd like to work on your order, and lastly, providing the payment. And to cap it all up is their financial policy. They are the cheapest resume writers in the industry. With just $10, you can have a great resume delivered to you. And, of course, the price ranges depend on what you need. For example, the price mentioned above works best for high schoolers. However, for professional CVs, that would be about $20. Anyone conscious of the market's price trends, especially among online writing services, will attest to this being a low price. And it does not in any way affect the excellence of the delivery. #4. 99PAPERS 99Papers has left a strong footprint in the market as one of the strongest online writing service brands. They are not new to the space. Thus, they have many reviews to their credit. Many a client have established a trust connection with them over the years. And the reason for this is not far-fetched. It is hinged upon that they deliver premium quality jobs when their work is ordered. They are not just fundamental in their approach to customer satisfaction. They are with you every step until your job gets to the finished stage. Why are they trusted in the market? Because they have distinguished themselves when it comes to pricing, discount programs, excellent deliveries, and outstanding customer satisfaction. These are basic things to note when you want to order from any professional executive resume writing service around. The excellent delivery they pride themselves in is owing to a competent team of professional writers. And even though 99Papers has academic writing as the major aspect of their writing services, they still offer additional career-related services such as personal statements and resume writing. And with expert freelance writers from New York not being novices in the market, they are reliable to churn in excellent deliveries consistently on the platform. Another major reason most people patronize them is the pricing. With $12.60, you would get a standard resume with 15-day delivery. And for their premium plan, you get to pay $22.05 for their 15-day delivery resume. And just like many other platforms, many dynamics are at play around the pricing. A good example is a deadline. You are charged extra fees if it is shorter than what's stipulated in the service. The same goes for your career level. A high-schooler resume's price is lower than an executive-level CV. And with many customer reviews online, you will conclude that 99Papers is the hub of high-quality resumes for executives. Furthermore, this specific platform has a bidding system where you pick the writer that works on your resume. It is after this phase that you get charged on their website. And yes, they have a loyalty program that affords you a 5% discount on each resume you order. And you can make use of this discount on future orders as well. However, this discount only lasts for a total of 5 years. To get access to a lifetime discount, you might need to prep your wallet for that. #5. IVORY RESEARCH Getting the best writing done for your academic pursuits has never been easier. With Ivory Research, they take your writings from where it is to where you desire them to be. Especially Curriculum Vitae (CV), resumes, personal statements, dissertations, cover letters, theses, and other academic writings. Technical writings like these are their forte. And in the UK, they have established their brand as a valuable asset for every student and non-student seeking to get premium work done. They exist to help you achieve your academic, business, or even personal goals. Thus, they have curated a team of specialist writers who are academics themselves. This is to get the best hands to work on your military resume and other writing needs. Little wonder many of their clients are repeat customers. The quality of work delivered always brings them back. This company prides itself in on-time delivery of all the work you order from them. Their expert writers facilitate this as well. That is, this army of writers deliver excellent writing, original and plagiarism-free content, as well as prompt response to the deadline. Alongside this is the fact that they also render proofreading and editing services. So, not only can they craft your resume from scratch, but they can also help you take it from mere to exceptional. Ivory Research prides itself on a solid customer support system. You will not be left stranded as a customer reaching out to them. Many clients have become repeat customers because of the quick and detailed interaction that the Ivory research support team affords them. In the same vein, you can be sure of anonymity when you order from them. You would not be afraid of your details being found randomly online. They keep the information of their clients 100% confidential. So, if you are looking to write a stellar resume or cv and want to be kept anonymous from the writer, this is an excellent option to explore. FREQUENTLY ASKED QUESTIONS What is resume writing? Resume writing is the act of creating your resume. As simple as this sounds, it fully captures the entire process. A resume in itself is a formal document that iterates your qualifications for a specific role you are looking to apply for. It highlights the most relevant information in your career pursuits that positions you as the best candidate for the position you are applying for. It is mainly accompanied by a cover letter expressing your interest in applying for that role. Noteworthy is the fact that most recruiters advocate for resumes to be one-paged or two-paged at most. Writing a resume is a process that requires careful detailing of specifics. This information is tailored particularly to the given role being applied for. Thus, as much as you could have a general resume, it is advisable to have specific resumes for each job application. The writers in these services help you highlight the best possible qualifications, background information, job history, certifications, and other details that make you a perfect fit for the role you are looking to occupy. They take your information and convert it into a page that helps to endear you to the recruiter. Resume writing involves some form of technical templates to follow. Many recruiters will prefer it to be chronological. That is, it contains your recent job history in the order you took them on, as it relates to the current role. Also, it includes neatly arranged headings and sub-headings, margins, active language uses, and highlights of important achievements. Note that a resume makes use of professional fonts. How much does it cost to hire someone to write a resume? First, hiring someone to write a resume is a promising venture everyone should invest in. However, how much that costs now depends on each writer hired to write the resume. To write your resume, each writing service charges differently. However, one thing that stays consistent is the excellence of the delivery. The price also differs based on the peculiarities of the work. For instance, the price of writing a resume with a shorter deadline would be different than that which was delivered on the number of days stipulated by the writing platform. The same goes for the type of grade the resume is written for. The career level is a major determinant of the price range of hiring a writer on some of these professional writing services to craft an excellent resume. The price for a high schooler is way less than that of an executive client. Further, as noted earlier, different companies write resumes for different prices. 99Papers, for example, writes theirs for $12.60 with a 15-day delivery timeline. While with PaperHelp, you can get an excellent resume starting from $45. For Studdit, their price for a professional resume is about $20. So, it all boils down to checking out what platform works best for you. Their offering for their prices also matters. So, how much you should pay a resume service near you is not fixed or static. It depends on what each writing service offers and if you can get more for less. Is it worth paying for resume service? Definitely! One might even say it is more than worth paying for resume service. Writing a resume is a technical job. And thus, it requires a lot of expertise to be done well. Just like a dissertation, you might be low on chances of scoring high if you are writing it for the first time, with little prior knowledge on how to go about it. However, if an experienced writer takes on the job for you, your chances of being an A student drastically increase. Similarly, a resume is a major document you need to get the job of your dreams. So, if it is done shabbily, you might not get the desired result of getting a good flavor from the recruiter. It just makes sense, doesn't it? If you do not have the capacity or required skillset, you outsource it to persons who are experts at it. Thus, you position yourself to enjoy the results of getting your resume written by a specialist. Many writers in the writing services listed above have crafted CVs and resumes that landed a job for clients. Thus, it makes it worth it to pay for resume services. What is the best resume writing service in 2022? There are many writing services in the market. But one that stands out among the pack is PaperHelp. They are the best resume services near me and you in 2022. And the reason for their distinctiveness is not hard to decipher. They take their clients' satisfaction seriously. They are one of the oldest in the market. With 12 years of experience in the industry, they have serviced many customers who have gone on to land high-paying jobs. Their sea of professional writers creates stunning CVs, which help to attract recruiters. These writers are not aimlessly chosen. They undergo a strict recruitment process where only the best fit for the job is chosen. So, the people who are hands-on to serve you on the PaperHelp platform are the best of the best writing specialists hands available. Further, PaperHelp’s customer support is one of the best around. You are never in the dark about the progress of your work. You are given adequate feedback per time on where your work has gotten to. And you get to manage your order through email, SMS, the PaperHelp app, and via Facebook Messenger. What is the affordable resume writing service? Pricing for each writing platform is different. And as noted above, there are many factors responsible for different price changes and jerks. However, in the resume writing service industry today, the most affordable remains Studdit. With $20, you get an exceptionally high-quality resume delivered to you. And, of course, like many other platforms, customized deadlines, client requirements, and career levels can increase this price. However, you could have a standard resume written for you by an expert writer for just $10. And you will not worry about less quality. Some of their writers deliver ahead of the delivery date and still get a stellar job done. Thus, you are still provided with high-quality work with the super-cheap payment. And alongside these are freebies and several discounts their clients enjoy. For example, you can get up to 15% discount on your first purchase with them. Further, you have excellent customer support throughout your ordering journey with them. What is the best resume writing service in Australia? If you are a student or job applicant in Australia, a very reliable platform to get your resume written is 99Papers. Many things make them significant for the Australian market. One is that their professional writers write in English as their native language. Thus, details of a good command of the language, which recruiters look out for in your resume, will be well covered-for in the entire document. Further, 99Papers provides quality writing and prompt delivery. They respect your deadline, especially one you set before the work commenced. 99Papers gives you a good customer service experience. They are passionate about the quality of your user experience on their website and the overall itinerary of each client on their platform. So, if you are looking to write your resume, they are an excellent spot to check out online. Can I pay someone to update my resume? Yes, you sure can. Nothing works by mistake. If you realize that working on your resume, either drafting from scratch or updating it, will cause massive harm to your career journey, you should seek help. And this is why these online writing services carefully curated above were not haphazardly chosen but carefully curated to bring the best experience to you. Services like Ivory Research are vast in the work of editing and proofreading. Thus, they can be of great help in updating your resume. With specialist writers on their team, they are ready to take your resume several notches higher. Similarly, companies like 99Papers are available at your fingertips to help update your resume to fit. Seeing that each resume is important to specific role applications, they are hands-on and ready to add, remove, modify, and re-write your resume to hit the spot for your application. PaperHelp and Studdit are also platforms you can check out in the updating business. They are more than keen to ramp up your resumes for you. TOP Resume Writing Services: Conclusion In the end, what matters is that your resume is well-written, whether it was written by you or by an expert. Thus, it only makes sense for you to put your best foot forward. And sometimes, by writing it yourself, the resume might be less standard than you would like it to be. Or sometimes, we are just unable to write it due to work schedules or other factors and hindrances. So, why not hire one of these best resume writing services? They will deliver you from a lot of headaches. They are very easy to access and order from. Make sure you check them out today. Contact Details Resume Builders Megan Crow contact@101resumes.com

October 08, 2022 08:49 PM Eastern Daylight Time

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Ultrahuman launches on Kickstarter ahead of US market distribution

Ultrahuman

The world's most advanced metabolic fitness platform Ultrahuman has today launched its latest wearable, the Ultrahuman Ring, on popular US product launch platform Kickstarter as the company seeks to engage the creator community and innovate with biohackers all around the world. The campaign will run until 27th October 2022. The Ultrahuman Ring is a metabolism-tracking wearable that measures movement, sleep, and the body’s energy dynamics coupled with intelligent activity or recuperating recommendations, in real-time, to balance and take control of your health. Ultrahuman Ring’s deep insights empower you with quantifying metrics related to your general health such as Movement, Heart rate, HRV, and Sleep. The Ring provides a minimal form factor with no screens or vibrations keeping you away from constant notifications. You check your details when you want to, on the app, ensuring no intrusion in your daily activities. It also comes with a power packed 5-day battery life. It is designed for enduring usage conditions and workouts. The ring’s outer surface is made of a titanium body coated with tungsten carbide which is 5 times harder than tool steel making it remarkably scratch resistant. At the same time, comfort and minimalism is at the core of the product.This is ensured by the smooth inner shell of the ring that makes it comfortable during sleep and rest scenarios. Ultrahuman Ring works standalone or in combination with the existing advanced glucose monitoring platform, Ultrahuman M1, to offer users even deeper metabolic insights and more precise actionables for optimizing your health. Ultrahuman’s core values include the approach of “No One-Size-fits-all diet” and aim at optimising health for every individual through biomarkers by quantifying the response of each user’s diet, workout, and sleep on their platform. The personalisation of this data allows a user to deep dive into their own body and make data-driven decisions for a better lifestyle. The Ring launches at $219 an exclusive super early bird price for the creator community. The retail price is estimated to be upwards of $300. As of writing this, the Ultrahuman Ring has been funded 533% over the funding goal and stands at $259831. With the help of this funding from Kickstarter, Ultrahuman is aiming to reach a global audience and make health optimisation efficient for every individual. Global shipping of the Ultrahuman Ring purchases on Kickstarter begin January 2023 onwards. Mohit Kumar, Founder and CEO, Ultrahuman commented: “We have always believed in the power of biomarkers in terms of their ability to make health optimization more efficient. With the Ultrahuman ring and a new suite of metabolic biomarkers, you can now understand not just what’s affecting your glucose metabolism but also how to act on the insights in an efficient way. For eg. You could figure how much of your glucose metabolism is affected by the lack of sleep vs the food itself. This is a phenomenal leap in the world of biomarkers and allows us to study various factors around human health in a unique and much more impactful way than ever.” Ultrahuman is a venture-backed startup that has raised $25m to date. Their investors include Alpha Wave Incubation (AWI), which is backed by DisruptAD and managed by Falcon Edge, Steadview Capital, Nexus Venture Partners, Blume Ventures and Utsav Somani’s iSeed fund, and a range of marquee founders and angel investors including Tiger Global’s Scott Schleifer. About Ultrahuman Ultrahuman is the world's most advanced metabolic fitness platform. By using glucose and other biomarkers, Ultrahuman is helping people improve their energy levels, increase focus and avoid metabolic disorders. For more information and updates on Ultrahuman, please visit ultrahuman.com or follow us on Facebook, Instagram, Twitter, LinkedIn, and YouTube. Contact Details Bilal Mahmood +44 7714 007257 b.mahmood@stockwoodstrategy.com Company Website https://ultrahuman.com/

October 07, 2022 10:31 AM Eastern Daylight Time

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How Carbyne Closed an Oversubscribed Series C in the Middle of Financial Market Turmoil

Carbyne

This is a challenging year for tech companies, especially for entrepreneurs seeking funding for their next phase of growth. According to Pitchbook, VC funding was down 8% in the first six months of the year, driven by the sliding shares of mature tech companies. The NASDAQ composite index is down close to 25% through September. And yet, despite the liquidity crunch, Carbyne secured $56 million to invigorate the public safety industry with modern cloud-native technology. While I’ve raised capital at Carbyne and previously managed companies through the IPO process, this cycle was remarkably different. For Carbyne, this round will help us accelerate our global expansion and help us achieve our target of covering one billion people by 2024. Here are some important lessons I learned while closing this round in today’s treacherous fundraising environment. Expect a Roller Coaster Ride As we entered 2022, the financial markets were riding at all-time highs, and investors were looking to deploy their surplus cash in high-return opportunities like those offered by startups. Within a matter of weeks, the markets cratered, and pessimism spread rapidly across the financial markets. Unable to fulfill their own financial commitments, fund managers were looking to rationalize their positions, and the flight to safety was in full swing. We started the round right when the financial markets started to tumble, not expecting it would last throughout the year. A couple of times, the deal was on the cusp of closing and then, at the last moment, there was a surprise turn in the process. Investors’ sentiment changed almost overnight due to the macro environment, and we went back to square one. The key to riding the roller coaster of the fundraising process is to stay focused on investor feedback and to expect the unexpected. Be Flexible, Adapt Quickly to Changes, and Focus on the Right Investors Companies like Carbyne that successfully navigated the volatile markets of early 2022 got a few critical things right. For one, we realized that the tide was turning, and we adapted to the changes quickly. We adjusted our ask to investors, whose portfolios were reeling from the downturn. While we focused on the bull market case, we developed a base case and also bear case scenarios. Scenario modeling is key in a challenging market like this one – it’s crucial to show financial models that span from bull to bear case. We also continued engaging with more investors in our pipeline, targeting potential partners whose investing mandates would align with our mission and who would believe in our vision and guide us toward our North Star. Companies in fundraising mode should focus on finding investors who understand their business and are excited to join in their journey. Value choosing the right partner, even if they are not the highest bidder. Build Plan B and C Startups should always keep an ear to the ground and wake up earlier to shifting investor sentiment. Build lots of wiggle room into the process and prepare for unexpected delays within the plan. Right now, having just a plan A is not sufficient. Companies need to build plan B and plan C. Build these plans for base and bear cases without changing your vision and mission. We started the process a lot earlier and kept plans A, B, and C ready to execute. As they say, plan for the worst and prepare for the best. Be Open to Different Structures for the Round In cash-constrained environments, when it becomes difficult to raise equity, startups should calculate the cost of equity and the cost of debt. Be open to adjusting the size of the round, show investors your flexibility in the round size, and most importantly, build flexibility into your financial models. Don’t be afraid to explore alternative ways to raise capital, such as debt. We should dispel the stigma associated with raising debt financing since it can bring unique advantages. The cost of debt is usually lower than equity in the long run if you are confident in hitting your financial targets and forecasts. Furthermore, debt financing has the added benefit of not diluting existing investments. The environment today is much different than it was only a year ago. The key to successfully reaching your funding goals is to be agile and flexible while staying true to your mission. About Carbyne Carbyne (Headquartered in New York, NY) is a leading global provider of cloud-native mission-critical contact center solutions. Carbyne is one of the largest rich-data providers for emergency response centers, delivering over 250M data points per year all in a unified platform. Our technologies enable emergency contact centers and select enterprises to connect with callers as well as connected devices via highly secure communication channels without needing to download a consumer app. With a mission to redefine emergency collaboration and connect the dots between people, enterprises, and governments, Carbyne provides a unified cloud-native solution that provides live actionable data that can lead to more efficient and transparent operations and ultimately save lives. With Carbyne, every person counts. Contact Details For media inquiries please contact: Kerens@carbyne.com Company Website https://carbyne.com/

October 07, 2022 09:00 AM Eastern Daylight Time

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REPRISE BIOMEDICAL ANNOUNCES U.S. LAUNCH OF MIRO3D® THREE DIMENSIONAL RESORBABLE WOUND MATRIX

Reprise Biomedical

Reprise Biomedical, Inc., an innovative medical device company focused on developing and commercializing biologic solutions using its proprietary perfusion decellularization technology, has commenced U.S. sales of its Miro3D wound matrix through its direct U.S. sales force and independent sales agent network. Reprise received FDA 510(k) clearance for Miro3D on August 18, 2022, and initial clinical evaluations have already been successfully completed. Miro3D is a three-dimensional (2cm thick) biological matrix designed to be cut and shaped to fill deep or tunneling wound beds. Manufactured from decellularized porcine liver, Miro3D is a highly porous matrix which allows rapid cellular infiltration and integration in situ. Miro3D is the first U.S. commercially available wound matrix that is designed to fill a wound with its three-dimensional scaffold, rather than cover the wound with a traditional two-dimensional wound dressing. Dr. Moses Shieh of Lee Memorial Hospital and Surgical Healing Arts in Fort Myers, FL commented on his first clinical uses of Miro3D: “Miro3D has the potential to be a substantial advance in my wound care practice. My first cases included a stage IV sacral pressure ulcer which had been present for greater than 13 months and a post panniculectomy surgical dehiscence wound which had a 4cm medial undermining region, with both patients now progressing nicely toward full healing. Miro3D has volume and depth like no other product available in our health system. With these early clinical results, I am encouraged that Miro3D has the potential to drastically reduce length of stay in the hospital for patients with these complex wounds.” Dr. Brian Parkes of Scotland Memorial Hospital in Laurinburg, NC commented on his first clinical use of Miro3D: “I was eagerly awaiting FDA clearance of Miro3D since it provides a three-dimensional approach that was previously unavailable. My first Miro3D surgery was a necrotizing fasciitis patient who had a previously placed two-dimensional matrix but was experiencing delayed healing. Miro3D was easy to handle, robust to suture in place, and at follow-up, the results were remarkable. The wound responded with great granulation within just five days, and was ready for skin grafting, something that I would never have expected in this type of patient.” Carrie Powers, CEO of Reprise Biomedical, added the following: “We are excited to advance the treatment of deep and tunneling wounds, a U.S. market opportunity we estimate at over $1.4 billion annually, with our launch of the transformative Miro3D wound matrix. Because the most difficult to treat wounds are three-dimensional, advanced wound care surgeons have been asking for a product that can fill the wound, rather than just cover it. Our launch of Miro3D is Reprise’s first step in offering a range of three-dimension matrices with unique delivery systems designed to treat deep wounds and improve patient lives by quickening their recovery." About Miro3D Miro3D is available in four sizes (2x2cm, 3x3cm, 5x5cm and 5x10cm), with all sizes having a thickness of 2cm. Miro3D is also available in a Fibers configuration, consisting of a tray of loose fibrillar strands designed for packing small crevices and tunnels in wound beds. Photographs of Miro3D and before and after photographs of initial clinical uses are available on Reprise’s website at reprisebio.com/Miro3D. Miro3D wound matrix is intended for the management of wounds including: partial and full thickness wounds; pressure ulcers; venous ulcers; chronic vascular ulcers; diabetic ulcers; tunneled, undermined wounds; trauma wounds (abrasions, lacerations, second-degree burns, and skin tears); draining wounds; and surgical wounds (donor sites/grafts, post-Mohs surgery, post-laser surgery, podiatric, wound dehiscence). About Reprise Biomedical Reprise Biomedical’s mission is to deliver solutions to the unmet clinical needs of physicians in biological medical device markets. To learn more about Reprise Biomedical and its medical devices, visit reprisebio.com. ### Contact Details Reprise Biomedical, Inc. Carrie L Powers +1 763-284-6780 cpowers@reprisebio.com Company Website https://reprisebio.com

October 06, 2022 04:00 PM Central Daylight Time

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World Mental Health Day Press Conference with National Experts on Mental Health

Shatterproof

On World Mental Health Day (Monday, October 10), more than 180 leaders from across the country are gathering to launch a national movement to end the stigma around mental health and substance use disorders. World Mental Health Day kicks off the two-day Summit where organizations representing different industries and sectors, including federal and NGOs, will unite their drive and expertise to create powerful strategic actions to end the shame and prejudice caused by stigma. Media is invited to attend the press conference in person or virtually via Zoom. Leaders will speak for 2-3 minutes followed by Q&A. One-on-one interviews will be available following the Q&A. Who: National leaders on mental health and substance use disorders including: ● Kristin Kroeger, Chief of Programs, Policy, & Partnerships, American Psychiatric Association ● Jared Skillings, Chief of Professional Practice, American Psychological Association ● John MacPhee, Chief Executive Officer, The Jed Foundation ● Gary Mendell, Founder and CEO, Shatterproof ● Eve Byrd, Director of Mental Health Programs, Carter Center ● Janet Lindow, PhD, Executive Director & Co-Founder, Rural Behavioral Health Institute Complete list of national organizations attending the Summit When: Monday, October 10. Media preset time is 12:25 p.m. Press conference will begin promptly at 12:30 p.m. (MST) Where: Cliff Lodge, Snowbird Resort (Entry 4), Primrose B (Floor L) 9320 Cliff Lodge Dr, Snowbird, UT 84092 Or Virtual via Zoom Meeting ID: 925 7820 1741 Password: summit Why: 1 in 5 U.S. adults experience mental illness each year and substance use disorder affects more than 20 million Americans aged 12 and over. Moreover, 9.5 million adults over 18 have both a substance abuse disorder and a mental illness. While the numbers of people experiencing mental health and substance use disorders are staggering, stigma often prevents individuals and many communities from seeking the help they need. Visuals: Press conference and a collaborative session on road mapping the path to end the stigma around mental health and substance use disorders. About Shatterproof: Shatterproof is a national nonprofit organization dedicated to reversing the addiction crisis in the U.S. Shatterproof harnesses the models of business, the rigor of science and the power of a national movement to create change and save lives through three pillars of work: revolutionizing the addiction treatment system, breaking down addiction-related stigmas and supporting and empowering our communities. Find Shatterproof on Facebook, Twitter and YouTube: @ShatterproofHQ or follow them on Instagram at @weareshatterproof. To learn more, visit www.Shatterproof.org. Contact Details Shatterproof Lauren Lawson-Zilai +1 240-910-5483 press@shatterproof.org Huntsman Mental Health Institute Jerilyn Stowe +1 801-243-5764 jerilyn.stowe@hsc.utah.edu R&R Partners Kelsey Richardson +1 801-913-9454 kelsey.richardson@rrpartners.com Company Website https://www.shatterproof.org/

October 06, 2022 03:20 PM Eastern Daylight Time

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AmeriLife Partners with Senior Services of Illinois

AmeriLife

AmeriLife Group, LLC (“AmeriLife”), a national leader in developing, marketing, and distributing life and health insurance, annuities and retirement planning solutions, announced today that it has partnered with Senior Services of Illinois, Inc. Alongside its sister company Consumers Direct Insurance Services, Inc. as well as licensed insurance agency ToInsure.me, Senior Services of Illinois is a market leader in delivering quality insurance services and customer advocacy to Medicare beneficiaries and retirees across the midwestern and western United States. Per the agreement, terms of the deal were not disclosed. "We’re excited to join forces with AmeriLife and add our name to an incredible roster of brands and businesses,” said Scott Loochtan, founder and president of Senior Services of Illinois. “Most importantly, Senior Services of Illinois’s same customer-first approach will continue. The future is bright, and we look forward to growing together." Headquartered in Riverwoods, Ill., and founded in 1997 by Loochtan out of his father’s candy factory, Senior Services of Illinois has grown to serve more than 30,000 clients across five states, including New Mexico, Oklahoma, Colorado and Texas. As an independent, authorized exclusive general agent for Blue Cross and Blue Shield of Illinois, the company prides itself on offering its clients both exemplary service and quality insurance services. Despite its tremendous growth over the years, Senior Services of Illinois has remained true to its family roots, and its team of dedicated education specialists and customer advocates are a testament to the company’s people-first approach that has allowed it – and its clients – to thrive. “Senior Services of Illinois has proven to not only be an incredibly performative company, but one whose culture and values aligns perfectly with ours,” said Mike Vietri, AmeriLife’s Chief Distribution Officer. “We couldn’t be happier to welcome Scott and his team to the AmeriLife family, and look forward to accelerating their growth with the industry-leading resources, technology and expertise that’s become the hallmark of AmeriLife’s growing Distribution.” ### About Senior Services of Illinois Senior Services of Illinois, Inc. (SSI), alongside its sister company, Consumers Direct Insurance Services, Inc. (CDIS) and licensed insurance agency ToInsure.me, is an independent, authorized exclusive general agent for Blue Cross and Blue Shield of Illinois. A family-run business based in Riverwoods, Ill., with offices in New Mexico, Oklahoma and Texas, SSI prides itself on providing clients with exemplary service and quality insurance solutions. For more information, visit SSIInsure.com. About AmeriLife AmeriLife’s strength is its mission: to provide insurance and retirement solutions to help people live longer, healthier lives. In doing so, AmeriLife has become recognized as the leader in developing, marketing, and distributing life and health insurance, annuities and retirement planning solutions to enhance the lives of pre-retirees and retirees across the United States. For more than 50 years, AmeriLife has partnered with top insurance carriers to provide value and quality to customers served through a distribution network of over 300,000 insurance agents and advisors and more than 100 marketing organizations and insurance agency locations nationwide. For more information, visit AmeriLife.com, and follow AmeriLife on Facebook and LinkedIn. Contact Details Media Jeff Maldonado +1 321-297-1112 jmaldonado@amerilife.com Partnership Inquiries Patrick Nichols +1 727-726-0726 pnichols@amerilife.com Company Website https://amerilife.com/

October 06, 2022 02:00 PM Eastern Daylight Time

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